Heart failure is a significant public health concern, with a 20-40% risk of developing the disease. The heart can adapt to different conditions to maintain continuous blood flow and meet the body's demands. However, the molecular mechanisms behind physiological and pathological adaptations are complex and not well understood. Ischemic stress can damage the heart, resulting in myocardial infarction, heart failure, and ischemic heart disease. Identification of novel genes for controlling stress adaptation in the heart will be decisive to protect against ischemia/reperfusion and to enhance cardiac function, potentially leading to improved grafts for xenotransplantation. We created pigs to reduce oxidative stress in the cells, conducted molecular analyses, and carried out functional assays. We subjected porcine kidney fibroblasts (pKDNF) to a stress tests using hydrogen peroxide (H₂O₂), and evaluated cell death by using multiple assays. The findings revealed that transgenic cells exhibited greater resilience to stress, with a reduction in apoptosis, MPT-mediated necrosis, ferroptosis and superoxide (O₂^-) formation. Our recent results demonstrate that transgenic cells are protected against oxidative stress and various types of cell death, raising the possibility of using pigs with improved grafts for xenotransplantation in the future.