This presentation provides a comprehensive overview of our research on amniotic epithelial cells, sharing both our past achievements and ongoing projects.
Our work has demonstrated the immense potential of amniotic epithelial cells for clinical applications, underpinned by their stem cell characteristics, non-tumorigenic nature, immunotolerance, and remarkable immunomodulatory properties. Notably, we've showcased their ability to differentiate into functional cells with metabolic functions, such as liver cells, and have validated their therapeutic efficacy in animal models of congenital metabolic disorders.
More recently, our research has unveiled two novel facets of amniotic epithelial cells. First, we've discovered their role in exosome secretion and their involvement in liver fibrosis. Second, we are investigating their capacity for intercellular mitochondrial horizontal transfer.
Furthermore, employing cutting-edge single-cell RNA sequencing analysis through bioinformatics, we've unveiled the previously elusive potential of amniotic epithelial cells to virtually replicate the placental function during pregnancy, a groundbreaking revelation.
By sharing these updates, I hope to accelerate the progress of the amniotic epithelial cell research.
